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Dr. Megan O¡¯Brien¡¯s research uses wearable and mobile technologies to measure, monitor, and improve rehabilitation outcomes. She applies interdisciplinary methods in engineering, biomechanics, and machine learning to identify disease-specific biomarkers of health and behavior across the continuum of care, from the clinic to the home. She also evaluates practical, technology-based interventions, including assistive and therapeutic devices and digital health platforms, for their impact on patient outcomes. Dr. O'Brien's research spans diverse clinical populations, including stroke, spinal cord injury, Parkinson¡¯s disease, cerebral palsy, and pediatrics.

Prior to joining the Shirley Ryan Â鶹APP, Dr. O'Brien's work in motor control and neuroeconomics examined the influence of risk, reward, and effort on movement-based decision making. 

Dr. O'Brien is the associate director of the Technology & Innovation Hub and the scientific principal investigator on BACPACS, a NIDILRR-funded Rehabilitation Engineering Â鶹APP Center (RERC).